I run a Linux virtual machine on my Mac laptop. This allows me to keep my development environment and production environments perfectly in sync (and make snapshots for easy experimentation / rollback). I've found VMWare Fusion works the best, but there are free open source alternatives such as VirtualBox if you just want to get your feet wet.
I share the source folders from the guest Linux operating system on my Mac and edit them with the Mac source editor of my choosing (I use Eclipse / PyDev because the otherwise excellent TextMate doesn't deal well with Chinese text yet). I've documented the software setup for the guest Linux operating system here; it's optimized for serving multiple Django applications (including geodjango).
For extra added fun, you can edit your Mac's /etc/hosts file to make yourdomainname.com resolve to your guest Linux boxes internal IP address and have a simple way to work on / test multiple web projects online or offline without too much hassle.